Cellular Respiration
What is Respiration?
Cellular Respiration is the process that takes place in cells to convert food into energy. This process is also known as internal respiration. In order to release the maximal amount of energy, the molecules of Carbon, Hydrogen, Oxygen and Nitrogen which make up our food are stored as a high energy molecule known as ATP or Adenosine Triphosphate.
What is Respiration?
Cellular Respiration is the process that takes place in cells to convert food into energy. This process is also known as internal respiration. In order to release the maximal amount of energy, the molecules of Carbon, Hydrogen, Oxygen and Nitrogen which make up our food are stored as a high energy molecule known as ATP or Adenosine Triphosphate.
The Products of Respiration
When energy is needed, ATP is broken down using an enzyme (known as ATPase) into ADP (Adenosine Diphosphate). This process breaks the high energy Phosphate (P) bond and so provides energy for use by the body. Here is the equation you may see in text books:
ATP = ADP + P +Energy
The human body is also capable of resynthesising ATP to allow it to continue producing energy. To do this it must use energy to reverse the equation shown above. This is known as an endothermic reaction as it requires energy. The breakdown of ATP is called exothermic as it produces energy. The process of breaking down and resynthesising ATP is efficient at producing energy as less energy is required to resynthesis the ATP than is made to break it down. Here is the Resynthesis equation:
Energy + ADP +P = ATP
What are the Energy Systems?indeed
There are two energy systems used in during the process of respiration. Aerobic Respiration, meaning 'with oxygen' which is used for long-term, steady paced exercise and day-to-day activities and Anaerobic Respiration or 'without oxygen' which produces fast bursts of energy for short, powerful bursts. The Anaerobic system can be divided into two further systems, ATP-PC and Lactic acid. All energy systems work together, but the intensity and type of activity will determine which system is predominant.
•Aerobic system
•Anaerobic system
1.ATP-PC system
2.Lactic Acid System
Aerobic Respiration:
The aerobic system produces the largest amounts of energy, although at the lowest intensity. At the start of exercise the body cannot deliver oxygen to the muscles fast enough to initiate the complex chemical reactions which occur during aerobic metabolism. Therefore the body relies on anaerobic processes for the first couple of minutes.
The aerobic system can be broken down into three sections:
•Glycolysis
•Kreb's Cycle
•Electron Transport Chain (ETC)
Aerobic Glycolysis
Glycolysis is the breakdown of Carbohydrates (in the form of Glucose or Glycogen) into Pyruvic acid and resulting in the production of two ATP molecules. A total of 10 chemical reactions are required to convert Carbohydrates into Pyruvic acid which take place in the muscle Sarcoplasm. Gylcosis can take place without the presence of Oxygen in the cells however on finishing Glycosis the cell decides which process to carry out. If Oxygen is present then the cell will perform Oxygen Respiration (aerobic respiration) and continue on to Kreb's Cycle.
Kreb's Cycle
Sometimes also known as the Citric acid cycle, or the Tricarboxylic acid cycle, this is the second phase in the process of aerobic metabolism. The Pyruvic acid produced during Glycolysis enters the mitochondria and is immediately converted to Acetyl Conzyme A which combines with Oxaloacetic acid to form a 6 carbon compound, known as Citric acid.
Further chemical reactions occur to wield enough energy to resynthesise 2 ATP molecules. Bi-products of these reactions include Carbon Dioxide (CO2), which is exhaled by the lungs and Hydrogen (H) which is transported to the site of the Electron Transport Chain by carrier molecules NAD+ and FAD. The process is termed a cycle due to the starting product of Oxaloacetic acid is also the end product, ready to start the process over again.
The aerobic system produces the largest amounts of energy, although at the lowest intensity. At the start of exercise the body cannot deliver oxygen to the muscles fast enough to initiate the complex chemical reactions which occur during aerobic metabolism. Therefore the body relies on anaerobic processes for the first couple of minutes.
The aerobic system can be broken down into three sections:
•Glycolysis
•Kreb's Cycle
•Electron Transport Chain (ETC)
Aerobic Glycolysis
Glycolysis is the breakdown of Carbohydrates (in the form of Glucose or Glycogen) into Pyruvic acid and resulting in the production of two ATP molecules. A total of 10 chemical reactions are required to convert Carbohydrates into Pyruvic acid which take place in the muscle Sarcoplasm. Gylcosis can take place without the presence of Oxygen in the cells however on finishing Glycosis the cell decides which process to carry out. If Oxygen is present then the cell will perform Oxygen Respiration (aerobic respiration) and continue on to Kreb's Cycle.
Kreb's Cycle
Sometimes also known as the Citric acid cycle, or the Tricarboxylic acid cycle, this is the second phase in the process of aerobic metabolism. The Pyruvic acid produced during Glycolysis enters the mitochondria and is immediately converted to Acetyl Conzyme A which combines with Oxaloacetic acid to form a 6 carbon compound, known as Citric acid.
Further chemical reactions occur to wield enough energy to resynthesise 2 ATP molecules. Bi-products of these reactions include Carbon Dioxide (CO2), which is exhaled by the lungs and Hydrogen (H) which is transported to the site of the Electron Transport Chain by carrier molecules NAD+ and FAD. The process is termed a cycle due to the starting product of Oxaloacetic acid is also the end product, ready to start the process over again.
Electron Transport Chain
The hydrogen mentioned above is transported into the inner membranes of the Mitochondria where it is split into a proton (H+) and an electron (H-). The electrons are then subject to a series of redox reactions which release a large amount of energy in order to resynthesise ATP.
The protons also create energy by moving back through the inner membrane of the Mitochondria because of the redox reactions. This causes an imbalance of H+ and so they return through the membrane, producing energy. A final exothermic reaction is the combination of hydrogen with oxygen, to form water. The total ATP production during all of the reactions of the electron transport chain is 34, meaning it is by far the highest producing phase of aerobic metabolism.
Aerobic Respiration Equation:
Glucose + Oxygen = Carbon Dioxide + Water + Energy
C6H12O6 + 6O2 = 6CO2 + 6H2O + Energy
Anaerobic Respiration:
The anaerobic energy system provides energy in the absense of Oxygen. This is used in the first few minutes of all exercise, before there is suffiecient oxygen available at the muscles for aerobic metabolism. It is also used for fast, powerful bursts of energy, for which the aerobic system is insufficient. There are two systems within Anaerobic metabolism, which are the ATP-PC system and the lactic acid system.
ATP-PC System
ATP as already discussed is a high energy molecule which is broken down to form ADP and release energy. PC or Phosphocreatine is another high energy molecule, found in the Sarcoplasm of muscle fibres. The breakdown of ATP and so increase in volume of ADP triggers an enzyme known as Creatine Kinase to initiate the breakdown of PC into Phosphate and Creatine. Being an exothermic reaction, this provides the energy required to resynthesise ATP at a fast rate.
We only have 120g of Creatine within our bodies and so this repeated breaking down of PC in order to produce energy to resynthesise ATP is temporary and can only last a maximum of 10 seconds. Therefore the ATP-PC system is used mainly for bursts of speed.
Lactic Acid System
Sometimes also known as Anaerobic Glycolysis due to the initial process being the same as aerobic glycolysis (as mentioned above), only without oxygen. So, as before 10 chemical reactions occur within the Sarcoplasm which turn Carbohydrate into Pyruvic acid and 2 molecules of ATP. The difference now being the lack of oxygen meaning the carrier molecule NAD+ cannot offload the Hydrogen (H+) by-product of glycolysis causing a build up in the cell.
To try to prevent an increase in acidity the pyruvic acid accepts the H+, forming Lactic acid. If oxygen was present the H+ would be transported to the Mitochondria for use in the Kreb's cycle. Lactic acid is thought to interefere with muscle contraction due to disrupting the binding of Calcium to Troponin. Acidity also stimulates free nerve endings within the muscle, causing pain. Due to lactic acid production, this energy system can only be predominant for up to 2 minutes.
Following anaerobic exercise, despite the metabolic process used not requiring oxygen, your body will be in Oxygen Debt and so your respiration rate will be very high.
Anaerobic Respiration Equation:
Glucose = Ethanol + Carbon Dioxide + Energy
C6H12O6 = 2C2H5OH + 2CO2 + Energy